This paper presents an information fusion method to diagnose system fault based on dynamic fault tree (DFT) analysis and dynamic evidential network (DEN). In the proposed method, firstly, it uses a DFT to describe the dynamic fault characteristics and evaluates the failure rate of components using interval numbers to deal with the epistemic uncertainty. Secondly, qualitative analysis of a DFT is to generate the characteristic function via a traditional zero-suppressed binary decision diagram, while quantitative analysis is to calculate some importance measures by mapping a DFT into a DEN. Thirdly, these reliability results are updated according to sensors data and used to design a novel diagnostic algorithm to optimize system diagnosis. Furthermore, a diagnostic decision tree (DDT) is obtained to guide the maintenance workers to recover the system. Finally, the performance of the proposed method is evaluated by applying it to a train-ground wireless communication system. The results of simulation analysis show the feasibility and effectiveness of this methodology